Endocrine Abstracts

Introduction: Accumulating evidence has shown that not only maternal health during pregnancy, but also the paternal metabolic status at the time of conception may have an impact on the subsequent health of the offspring. Cholestatic liver diseases are metabolic conditions characterised by increased circulating serum bile acid and lipid levels. In this study we hypothesised that paternal cholestasis alters disease susceptibility in the offspring.Methods: ...

Introduction: Accumulating evidence has shown that not only maternal health during pregnancy, but also the paternal metabolic status at the time of conception have an impact on the subsequent health of the offspring. Cholestatic liver diseases are metabolic conditions characterised by increased circulating serum bile acid and lipid levels. A previous study has shown that long-term cholestasis results in destruction of the blood–testis barrier and germ cell apoptosis. We h...